The Cantley lab welcomes a diverse set of talents and fosters an interdisciplinary approach in its attempts to translate fundamental scientific discoveries into clinical innovations.
Principal Investigator
Lewis C. Cantley, Ph.D.
Meyer Director of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medical College, Professor of Cancer Biology in Medicine
Lewis Cantley has made significant advances in cancer research, stemming from his discovery of the signaling pathway phosphoinositide 3-kinase (PI3K) in 1984. His pioneering research has resulted in revolutionary treatments for cancer, diabetes and autoimmune diseases. The author of over 400 original papers and more than 50 book chapters and review articles, Dr. Cantley is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Sciences. He graduated summa cum laude with a B.S. in chemistry from West Virginia Wesleyan College (1971) and obtained a Ph.D. in biophysical chemistry from Cornell University (1975). He conducted postdoctoral research at Harvard University, where he was appointed assistant professor of biochemistry and molecular biology in 1978. He became a professor of physiology at Tufts University in 1985, but returned to Harvard Medical School as professor of cell biology in 1992. He became chief of Harvard’s new Division of Signal Transduction, and a founding member of its Department of Systems Biology in 2002. In 2007, he was appointed director of the Beth Israel Deaconess Cancer Center. He joined the faculty of Weill Cornell Medical College and NewYork-Presbyterian Hospital in 2012.
Lab Members
Jacqueline Gonzalez B.Sc.
- Administrative Assistant to Dr. Lewis Cantley
Email: jag3002@med.cornell.edu
Phone: (646) 962-6132
Monica Rosen
- Lab Manager
- B.S.Pennsylvania State University
Email: mog2008@med.cornell.edu
Phone: (646) 962-6136
Jared Johnson Ph.D.
- Postdoctoral Associate
Research Focus: Molecular and biochemical approaches to the signaling and metabolism of cancers
- Ph.D.Cornell University
Email: jaj2017@med.cornell.edu
Ting-Yu (Molly) Lin
- Graduate Student
Research Focus: Regulation of NRF2 in the Non-Small Cell Lung Cancer (NSCLC).
- M.S.National Taiwan University (Taipei, Taiwan)
Email: til2013@med.cornell.edu
Valbona Luga Ph.D.
- Postdoctoral Associate
Research Focus: LKB1/AMPK Signaling and Peutz-Jeghers Syndrome
- Ph.D.University of Toronto (Canada)
- B.Sc.University of Toronto (Canada)
Email: val2007@med.cornell.edu
Bryan Ngo
- Graduate Student
Research Focus: (1) Defining the molecular basis of LKB1-HIPPO pathway mediated tumor suppression in KRAS-Driven Non-Small Cell Lung Cancer. (2) Identifying molecular convergence points between the Hippo Pathway and Phosphoinositide (PI) Kinases, with an emphasis on the Type II PI Kinase, PIP4K2s.
- B.S.University of California, Irvine
Email: brn2008@med.cornell.edu
Evan Noch M.D., Ph.D.
- Instructor, Department of Neurology
- Post-doctoral fellow
Research Focus: The molecular mechanisms of endogenous tumor-associated necrosis in glioblastoma as well as the regulation of glucose metabolism using targeted therapies and dietary strategies to treat glioblastoma. Within this research program, he uses patient-derived models of glioblastoma to better recapitulate the human disease state and employs a wide variety of available technologies and core facilities within the tri-institutional community. He hopes to improve not only patient outcomes and survival but also overall well-being during treatment, particularly with respect to tumor necrosis that can be a devastating aspect of this tumor type and a major adverse effect of current treatment.
- Ph.D.Temple University School of Medicine
- M.D.Temple University School of Medicine
- B.S.New York University
Email: ekn9001@med.cornell.edu
Ruth Silimon
- Graduate Student
Research Focus: Skeletal muscle growth, metabolism, and muscle loss in cancer.
Email: rus2014@med.cornell.edu
Junho Song
- Research Technician I
Research Focus: 1. Defining the molecular basis of BRAF pathway using Kinase Library.
2. Identifying signaling pathway of cancer and non-cancer cells using bioinformatic tools.
- BS. Biological Science specialization in NeuroscienceUniversity of Chicago
Email: jus4007@med.cornell.edu
Janet Sun
- Research Technician II
Research Focus: Type-2 PIP kinases and kinase signaling
- B.S.St. Lawrence University
Email: jys2005@med.cornell.edu
Samuel Taylor
- MD, PhD student
Research Focus: (1) Elucidating the mechanisms of intestinal tumor growth
(2) Dissecting the role of pyruvate kinase in modulating cellular nutrient utilization
(3) Characterizing metabolic adaptations to hostile cell environments
- BSYale University
Email: sat2031@med.cornell.edu
Neil Vasan MD, PhD
- Medical Oncologist at Memorial Sloan Cancer Center
- Postdoctoral Associate
Research Focus: Oncogenic PIK3CA mutations, and PI3K signaling in normal and cancer cells
- BSHarvard University
- MD, PhDYale University
Email: nev2003@med.cornell.edu
Jenny (Chan Ying) Wong
- Research Technician II
Research Focus: Kinase signaling
- M.S.City College of New York
- B.S.City College of New York
Email: chw2030@med.cornell.edu
David Wu
- Research Technician II
Research Focus: Maintaining mouse colonies and mouse experiments
- B.S.Stony Brook
Email: daw2031@med.cornell.edu
Tomer Yaron
- Graduate Student (Tri-I CBM)
Research Focus: (1) Computational development of the Kinase Library – a novel system for predicting upstream kinases for phosphorylation events.
(2) Phospho-antigens – investigating the presentation mechanism and specificity of phosphorylated antigens on MHC Class I.
(3) MHC Library – characterizing the binding specificity of different MHC Class I molecules.
- M.Sc.Bar-Ilan University, Israel.
- B.Sc.Bar-Ilan University, Israel.
Email: toy2005@med.cornell.edu