Cantley Lab

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Publications

Journal Article
MacLaughlin JA, Cantley LC, Holick MF.  1990.  1,25(OH)2D3 increases calcium and phosphatidylinositol metabolism in differentiating cultured human keratinocytes.. J Nutr Biochem. 1(2):81-7.
Walsh MJ, Brimacombe KR, Veith H, Bougie JM, Daniel T, Leister W, Cantley LC, Israelsen WJ, Heiden MGVander, Shen M et al..  2011.  2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.. Bioorg Med Chem Lett. 21(21):6322-7.
Cantley LC, Dalton WS, DuBois RN, Finn OJ, P Futreal A, Golub TR, Hait WN, Lozano G, Maris JM, Nelson WG et al..  2012.  AACR Cancer Progress Report 2012.. Clin Cancer Res. 18(21 Suppl):S1-100.
Lyssiotis CA, Cantley LC.  2014.  Acetate fuels the cancer engine.. Cell. 159(7):1492-4.
Cantley LC, Hammes GG.  1973.  Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol.. Biochemistry. 12(24):4900-4.
Soltoff SP, Avraham H, Avraham S, Cantley LC.  1998.  Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.. J Biol Chem. 273(5):2653-60.
Ruderman NB, Kapeller R, White MF, Cantley LC.  1990.  Activation of phosphatidylinositol 3-kinase by insulin.. Proc Natl Acad Sci U S A. 87(4):1411-5.
Varticovski L, Daley GQ, Jackson P, Baltimore D, Cantley LC.  1991.  Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.. Mol Cell Biol. 11(2):1107-13.
Toker A, Meyer M, Reddy KK, Falck JR, Aneja R, Aneja S, Parra A, Burns DJ, Ballas LM, Cantley LC.  1994.  Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.. J Biol Chem. 269(51):32358-67.
Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You M-H, Yao Y, Kondo A et al..  2015.  Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.. Nat Med. 21(5):457-66.
Carilli CT, Farley RA, Perlman DM, Cantley LC.  1982.  The active site structure of Na+- and K+-stimulated ATPase. Location of a specific fluorescein isothiocyanate reactive site.. J Biol Chem. 257(10):5601-6.
Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.  2008.  Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.. J Clin Invest. 118(5):1796-805.
Douris N, Melman T, Pecherer JM, Pissios P, Flier JS, Cantley LC, Locasale JW, Maratos-Flier E.  2015.  Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.. Biochim Biophys Acta. 1852(10 Pt A):2056-2065.
Aramburu J, Yaffe MB, López-Rodríguez C, Cantley LC, Hogan PG, Rao A.  1999.  Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.. Science. 285(5436):2129-33.
Perry B, Banyard J, McLaughlin ER, Watnick R, Sohn A, Brindley DN, Obata T, Cantley LC, Cohen C, Arbiser JL.  2007.  AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo.. Arch Dermatol. 143(4):504-6.
Manning BD, Cantley LC.  2007.  AKT/PKB signaling: navigating downstream.. Cell. 129(7):1261-74.
Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, Izumo S.  2002.  Akt/protein kinase B promotes organ growth in transgenic mice.. Mol Cell Biol. 22(8):2799-809.
Moritz A, Li Y, Guo A, Villén J, Wang Y, MacNeill J, Kornhauser J, Sprott K, Zhou J, Possemato A et al..  2010.  Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases.. Sci Signal. 3(136):ra64.
Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borrás AM, Gale C-M, Naumov GN, Yeap BY, Jarrell E, Sun J et al..  2006.  Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.. J Clin Invest. 116(10):2695-706.
Locasale JW, Cantley LC.  2010.  Altered metabolism in cancer.. BMC Biol. 8:88.
Hallmann D, Trümper K, Trusheim H, Ueki K, C Kahn R, Cantley LC, Fruman DA, Hörsch D.  2003.  Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha.. J Biol Chem. 278(7):5099-108.
Clower CV, Chatterjee D, Wang Z, Cantley LC, Heiden MGVander, Krainer AR.  2010.  The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.. Proc Natl Acad Sci U S A. 107(5):1894-9.
Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen C-H, Wen J, Asara J, McGraw TE et al..  2013.  AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.. Mol Cell. 49(6):1167-75.