Cantley Lab

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Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borrás AM, Gale C-M, Naumov GN, Yeap BY, Jarrell E, Sun J et al..  2006.  Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.. J Clin Invest. 116(10):2695-706.
Schulze H, Korpal M, Hurov J, Kim S-W, Zhang J, Cantley LC, Graf T, Shivdasani RA.  2006.  Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.. Blood. 107(10):3868-75.
Turk BE, Hutti JE, Cantley LC.  2006.  Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates.. Nat Protoc. 1(1):375-9.
Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, C Kahn R.  2006.  Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.. Cell Metab. 3(5):343-53.
Engelman JA, Luo J, Cantley LC.  2006.  The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.. Nat Rev Genet. 7(8):606-19.
Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW.  2006.  Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.. PLoS Biol. 4(2):e38.
Asara JM, Zhang X, Zheng B, Maroney LA, Christofk HR, Wu N, Cantley LC.  2006.  In-gel stable isotope labeling for relative quantification using mass spectrometry.. Nat Protoc. 1(1):46-51.
Asara JM, Zhang X, Zheng B, Christofk HH, Wu N, Cantley LC.  2006.  In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification.. J Proteome Res. 5(1):155-63.
Luo J, Sobkiw CL, Hirshman MF, M Logsdon N, Li TQ, Goodyear LJ, Cantley LC.  2006.  Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.. Cell Metab. 3(5):355-66.
Turk BE, Lee DH, Yamakoshi Y, Klingenhoff A, Reichenberger E, J Wright T, Simmer JP, Komisarof JA, Cantley LC, Bartlett JD.  2006.  MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen.. Biochemistry. 45(12):3863-74.
Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, C Kahn R.  2006.  Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.. Proc Natl Acad Sci U S A. 103(32):12093-7.
Shaw RJ, Cantley LC.  2006.  Ras, PI(3)K and mTOR signalling controls tumour cell growth.. Nature. 441(7092):424-30.
Engelman JA, Cantley LC.  2006.  The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors.. Clin Cancer Res. 12(14 Pt 2):4372s-4376s.
Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA.  2006.  Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.. Proc Natl Acad Sci U S A. 103(45):16882-7.