Cantley Lab

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Publications

2008
Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.  2008.  Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.. J Clin Invest. 118(5):1796-805.
Yuan TL, Choi HSoo, Matsui A, Benes C, Lifshits E, Luo J, Frangioni JV, Cantley LC.  2008.  Class 1A PI3K regulates vessel integrity during development and tumorigenesis.. Proc Natl Acad Sci U S A. 105(28):9739-44.
Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y et al..  2008.  Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.. Nat Med. 14(12):1351-6.
Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L.  2008.  Fate of a bioactive fluorescent wortmannin derivative in cells.. Bioconjug Chem. 19(1):130-7.
Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC et al..  2008.  Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.. J Clin Invest. 118(9):3065-74.
Asara JM, Christofk HR, Freimark LM, Cantley LC.  2008.  A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen.. Proteomics. 8(5):994-9.
Christofk HR, Heiden MGVander, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC.  2008.  The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.. Nature. 452(7184):230-3.
Organ CL, Schweitzer MH, Zheng W, Freimark LM, Cantley LC, Asara JM.  2008.  Molecular phylogenetics of mastodon and Tyrannosaurus rex.. Science. 320(5875):499.
Shaywitz AJ, Courtney KD, Patnaik A, Cantley LC.  2008.  PI3K enters beta-testing.. Cell Metab. 8(3):179-81.
Yuan TL, Cantley LC.  2008.  PI3K pathway alterations in cancer: variations on a theme.. Oncogene. 27(41):5497-510.
Christofk HR, Heiden MGVander, Wu N, Asara JM, Cantley LC.  2008.  Pyruvate kinase M2 is a phosphotyrosine-binding protein.. Nature. 452(7184):181-6.
Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L.  2008.  Slow self-activation enhances the potency of viridin prodrugs.. J Med Chem. 51(15):4699-707.
Engelman JA, Cantley LC.  2008.  A sweet new role for EGFR in cancer.. Cancer Cell. 13(5):375-6.
2007
Perry B, Banyard J, McLaughlin ER, Watnick R, Sohn A, Brindley DN, Obata T, Cantley LC, Cohen C, Arbiser JL.  2007.  AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo.. Arch Dermatol. 143(4):504-6.
Manning BD, Cantley LC.  2007.  AKT/PKB signaling: navigating downstream.. Cell. 129(7):1261-74.
Lee JY, Engelman JA, Cantley LC.  2007.  Biochemistry. PI3K charges ahead.. Science. 317(5835):206-7.
Abbott DW, Yang Y, Hutti JE, Madhavarapu S, Kelliher MA, Cantley LC.  2007.  Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.. Mol Cell Biol. 27(17):6012-25.
Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D et al..  2007.  Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis.. Proc Natl Acad Sci U S A. 104(19):8077-82.
Holt LJ, Hutti JE, Cantley LC, Morgan DO.  2007.  Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis.. Mol Cell. 25(5):689-702.
Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, Abbott DW.  2007.  IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.. Mol Cell Biol. 27(21):7451-61.
Asara JM, Garavelli JS, Slatter DA, Schweitzer MH, Freimark LM, Phillips M, Cantley LC.  2007.  Interpreting sequences from mastodon and T. rex.. Science. 317(5843):1324-5.