Cantley Lab

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Locasale JW, Cantley LC.  2011.  Metabolic flux and the regulation of mammalian cell growth.. Cell Metab. 14(4):443-51.
Heiden MGVander, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM et al..  2011.  Metabolic pathway alterations that support cell proliferation.. Cold Spring Harb Symp Quant Biol. 76:325-34.
Yi CH, Pan H, Seebacher J, Jang I-H, Hyberts SG, Heffron GJ, Heiden MGVander, Yang R, Li F, Locasale JW et al..  2011.  Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.. Cell. 146(4):607-20.
Gao D, Inuzuka H, Tan M-KMarcus, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Y Chin R, Shaik S et al..  2011.  mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.. Mol Cell. 44(2):290-303.
Mullarky E, Mattaini KR, Heiden MGVander, Cantley LC, Locasale JW.  2011.  PHGDH amplification and altered glucose metabolism in human melanoma.. Pigment Cell Melanoma Res. 24(6):1112-5.
Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H et al..  2011.  Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.. Nat Genet. 43(9):869-74.
Yu Y, Yoon S-O, Poulogiannis G, Yang Q, Ma XMax, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP et al..  2011.  Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.. Science. 332(6035):1322-6.
Christofk HR, Wu N, Cantley LC, Asara JM.  2011.  Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries.. J Proteome Res. 10(9):4158-64.
Saci A, Cantley LC, Carpenter CL.  2011.  Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.. Mol Cell. 42(1):50-61.
Ebi H, Corcoran RB, Singh A, Chen Z, Song Y, Lifshits E, Ryan DP, Meyerhardt JA, Benes C, Settleman J et al..  2011.  Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.. J Clin Invest. 121(11):4311-21.
Evans AS, Lazar EJ, Tiase VL, Fleischut PM, Bostwick SB, Hripcsak G, Liebowitz R, Forese LL, Kerr G.  2011.  The role of housestaff in implementing medication reconciliation on admission at an academic medical center.. Am J Med Qual. 26(1):39-42.
Fleischut PM, Evans AS, Nugent WC, Faggiani SL, Lazar EJ, Liebowitz RS, Forese LL, Kerr GE.  2011.  Ten years after the IOM report: Engaging residents in quality and patient safety by creating a House Staff Quality Council.. Am J Med Qual. 26(2):89-94.
Bouskila M, Esoof N, Gay L, Fang EH, Deak M, Begley MJ, Cantley LC, Prescott A, Storey KG, Alessi DR.  2011.  TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.. Biochem J. 437(1):157-67.
Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ERose, Haviv S, Asara JM, Pandolfi PPaolo, Cantley LC.  2011.  Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.. Sci Signal. 4(163):ra13.
Yang X, Turke AB, Qi J, Song Y, Rexer BN, Miller TW, Janne PA, Arteaga CL, Cantley LC, Engelman JA et al..  2011.  Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer.. Cancer Res. 71(18):5965-75.
Moritz A, Li Y, Guo A, Villén J, Wang Y, MacNeill J, Kornhauser J, Sprott K, Zhou J, Possemato A et al..  2010.  Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases.. Sci Signal. 3(136):ra64.
Locasale JW, Cantley LC.  2010.  Altered metabolism in cancer.. BMC Biol. 8:88.
Clower CV, Chatterjee D, Wang Z, Cantley LC, Heiden MGVander, Krainer AR.  2010.  The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.. Proc Natl Acad Sci U S A. 107(5):1894-9.
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HGyung, Jin S, Keenan MC et al..  2010.  Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.. Nature. 465(7300):966.
Takeuchi H, Takeuchi T, Gao J, Cantley LC, Hirata M.  2010.  Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking.. Mol Cell Biol. 30(7):1689-702.
Engelman JA, Cantley LC.  2010.  Chemoprevention meets glucose control.. Cancer Prev Res (Phila). 3(9):1049-52.
Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T et al..  2010.  Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.. Cell Metab. 12(6):619-32.
Lee SHyun, Poulogiannis G, Pyne S, Jia S, Zou L, Signoretti S, Loda M, Cantley LClayton, Roberts TM.  2010.  A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice.. Proc Natl Acad Sci U S A. 107(24):11002-7.
Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M et al..  2010.  Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.. PLoS One. 5(5):e10504.
Shiga K, Takayama K, Futaki S, Hutti JE, Cantley LC, Ueki K, Ono Y, Mukai H.  2010.  Development of an intracellularly acting inhibitory peptide selective for PKN.. Biochem J. 425(2):445-53.