Cantley Lab

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Publications

2012
Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB.  2012.  p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.. Cell Metab. 16(1):104-12.
Comb WC, Hutti JE, Cogswell P, Cantley LC, Baldwin AS.  2012.  p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation.. Mol Cell. 45(6):719-30.
Das S, Aiba T, Rosenberg M, Hessler K, Xiao C, Quintero PA, Ottaviano FG, Knight AC, Graham EL, Boström P et al..  2012.  Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling.. Circulation. 126(18):2208-19.
Anastasiou D, Yu Y, Israelsen WJ, Jiang J-K, Boxer MB, Hong BSoo, Tempel W, Dimov S, Shen M, Jha A et al..  2012.  Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.. Nat Chem Biol. 8(10):839-47.
Lyssiotis CA, Cantley LC.  2012.  SIRT6 puts cancer metabolism in the driver's seat.. Cell. 151(6):1155-6.
Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X et al..  2012.  Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.. Chem Biol. 19(9):1187-98.
Quayle SN, Lee JY, Cheung LWT, Ding L, Wiedemeyer R, Dewan RW, Huang-Hobbs E, Zhuang L, Wilson RK, Ligon KL et al..  2012.  Somatic mutations of PIK3R1 promote gliomagenesis.. PLoS One. 7(11):e49466.
Benes CH, Poulogiannis G, Cantley LC, Soltoff SP.  2012.  The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility.. Oncogene. 31(5):653-63.
Myers AP, Cantley LC.  2012.  Sugar free, cancer free? Nutrition. 28(10):1036.
Garcia-Cao I, Song MSup, Hobbs RM, Laurent G, Giorgi C, de Boer VCJ, Anastasiou D, Ito K, Sasaki AT, Rameh L et al..  2012.  Systemic elevation of PTEN induces a tumor-suppressive metabolic state.. Cell. 149(1):49-62.
2011
Walsh MJ, Brimacombe KR, Veith H, Bougie JM, Daniel T, Leister W, Cantley LC, Israelsen WJ, Heiden MGVander, Shen M et al..  2011.  2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.. Bioorg Med Chem Lett. 21(21):6322-7.
Nardella C, Lunardi A, Patnaik A, Cantley LC, Pandolfi PPaolo.  2011.  The APL paradigm and the "co-clinical trial" project.. Cancer Discov. 1(2):108-16.
Yuan TL, Wulf G, Burga L, Cantley LC.  2011.  Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations.. Curr Biol. 21(3):173-83.
Wang X-S, Shankar S, Dhanasekaran SM, Ateeq B, Sasaki AT, Jing X, Robinson D, Cao Q, Prensner JR, Yocum AK et al..  2011.  Characterization of KRAS rearrangements in metastatic prostate cancer.. Cancer Discov. 1(1):35-43.
Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K et al..  2011.  Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis.. Mol Cell. 44(6):878-92.
Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DMF, Whitworth AJ, Alessi DR, Muqit MMK.  2011.  Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.. Open Biol. 1(3):110012.
Hara Y, Balci-Hayta B, Yoshida-Moriguchi T, Kanagawa M, de Bernabé DBeltrán-V, Gündeşli H, Willer T, Satz JS, Crawford RW, Burden SJ et al..  2011.  A dystroglycan mutation associated with limb-girdle muscular dystrophy.. N Engl J Med. 364(10):939-46.
Gandhi K, Lindenmuth DM, Hadzic A, Xu D, Patel VS, Maliakal TJ, Gadsden JC.  2011.  The effect of stimulating versus conventional perineural catheters on postoperative analgesia following ultrasound-guided femoral nerve localization.. J Clin Anesth. 23(8):626-31.
Cantley LC, Baselga J.  2011.  The era of cancer discovery.. Cancer Discov. 1(1):1.
Tsou P, Zheng B, Hsu C-H, Sasaki AT, Cantley LC.  2011.  A fluorescent reporter of AMPK activity and cellular energy stress.. Cell Metab. 13(4):476-86.
Locasale JW, Cantley LC.  2011.  Genetic selection for enhanced serine metabolism in cancer development.. Cell Cycle. 10(22):3812-3.
Cheung LWT, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, Lu Y, Stemke-Hale K, Dyer MD, Zhang F et al..  2011.  High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.. Cancer Discov. 1(2):170-85.
Shyh-Chang N, Zheng Y, Locasale JW, Cantley LC.  2011.  Human pluripotent stem cells decouple respiration from energy production.. EMBO J. 30(24):4851-2.
Lee JY, Chiu Y-H, Asara J, Cantley LC.  2011.  Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains.. Proc Natl Acad Sci U S A. 108(34):14157-62.
Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang J-K, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS et al..  2011.  Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.. Science. 334(6060):1278-83.