Cantley Lab

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Publications

2013
Yuan P, Ito K, Perez-Lorenzo R, Del Guzzo C, Lee JHyun, Shen C-H, Bosenberg MW, McMahon M, Cantley LC, Zheng B.  2013.  Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma.. Proc Natl Acad Sci U S A. 110(45):18226-31.
Gallop JL, Walrant A, Cantley LC, Kirschner MW.  2013.  Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.. Proc Natl Acad Sci U S A. 110(18):7193-8.
Shen C-H, Yuan P, Perez-Lorenzo R, Zhang Y, Lee SXian, Ou Y, Asara JM, Cantley LC, Zheng B.  2013.  Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.. Mol Cell. 52(2):161-72.
Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW et al..  2013.  PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.. Cell. 155(2):397-409.
Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B et al..  2013.  Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation.. J Biol Chem. 288(24):17360-71.
Baker R, Lewis SM, Sasaki AT, Wilkerson EM, Locasale JW, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL.  2013.  Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.. Nat Struct Mol Biol. 20(1):46-52.
Shyh-Chang N, Daley GQ, Cantley LC.  2013.  Stem cell metabolism in tissue development and aging.. Development. 140(12):2535-47.
Chen S, Jiang X, Gewinner CA, Asara JM, Simon NI, Cai C, Cantley LC, Balk SP.  2013.  Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.. Sci Signal. 6(277):ra40.
Klempner SJ, Myers AP, Cantley LC.  2013.  What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway.. Cancer Discov. 3(12):1345-54.
2012
Cantley LC, Dalton WS, DuBois RN, Finn OJ, P Futreal A, Golub TR, Hait WN, Lozano G, Maris JM, Nelson WG et al..  2012.  AACR Cancer Progress Report 2012.. Clin Cancer Res. 18(21 Suppl):S1-100.
Anastasiou D, Cantley LC.  2012.  Breathless cancer cells get fat on glutamine.. Cell Res. 22(3):443-6.
Cantley LC, Baselga J.  2012.  Cancer Discovery at one year: the editors' interim analysis.. Cancer Discov. 2(1):vi.
Shaw RJ, Cantley LC.  2012.  Cell biology. Ancient sensor for ancient drug.. Science. 336(6083):813-4.
Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA et al..  2012.  Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer.. Cancer Discov. 2(11):1048-63.
Shaw RJ, Cantley LC.  2012.  Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice.. F1000 Biol Rep. 4:2.
Hutti JE, Porter MA, Cheely AW, Cantley LC, Wang X, Kireev D, Baldwin AS, Janzen WP.  2012.  Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε.. PLoS One. 7(7):e41494.
Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z.  2012.  ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.. Nat Cell Biol. 14(12):1295-304.
Wang Z, Chatterjee D, Jeon HYong, Akerman M, Heiden MGVander, Cantley LC, Krainer AR.  2012.  Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons.. J Mol Cell Biol. 4(2):79-87.
Hanai J-ichi, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP.  2012.  Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways.. J Cell Physiol. 227(4):1709-20.
Marinis JM, Hutti JE, Homer CR, Cobb BA, Cantley LC, McDonald C, Abbott DW.  2012.  IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling.. Mol Cell Biol. 32(13):2479-89.
Locasale JW, Melman T, Song S, Yang X, Swanson KD, Cantley LC, Wong ET, Asara JM.  2012.  Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma.. Mol Cell Proteomics. 11(6):M111.014688.
Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, Liu Y, Tupper T, Ouyang J, Li J et al..  2012.  A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.. Nature. 483(7391):613-7.
Grobelny BT, Rubin D, Fleischut PM, Rubens E, Mack PFogarty, Fink M, Placantonakis DG, Elowitz EH.  2012.  Neurosurgical management of symptomatic thoracic spinal ossification in a patient with fibrodysplasia ossificans progressiva.. J Neurosurg Spine. 16(3):285-8.
Soap J.  2012.  New Paper on building Drupal sites.
Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL et al..  2012.  Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.. Cell. 149(3):656-70.