Cantley Lab

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Publications

2013
Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen C-H, Wen J, Asara J, McGraw TE et al..  2013.  AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.. Mol Cell. 49(6):1167-75.
Anaesth BJ.  2013.  Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.
Carracedo A, Cantley LC, Pandolfi PPaolo.  2013.  Cancer metabolism: fatty acid oxidation in the limelight.. Nat Rev Cancer. 13(4):227-32.
Lunardi A, Ala U, Epping MT, Salmena L, Clohessy JG, Webster KA, Wang G, Mazzucchelli R, Bianconi M, Stack EC et al..  2013.  A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.. Nat Genet. 45(7):747-55.
Sadanandam A, Lyssiotis CA, Homicsko K, Collisson EA, Gibb WJ, Wullschleger S, Ostos LCGonzalez, Lannon WA, Grotzinger C, Del Rio M et al..  2013.  A colorectal cancer classification system that associates cellular phenotype and responses to therapy.. Nat Med. 19(5):619-25.
Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim H-S, Lamia KA, Rameh LE et al..  2013.  Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.. Cell. 155(4):844-57.
Shinoda G, Shyh-Chang N, T de Soysa Y, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI et al..  2013.  Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.. Stem Cells. 31(8):1563-73.
Yeo H, Lyssiotis CA, Zhang Y, Ying H, Asara JM, Cantley LC, Paik J-H.  2013.  FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.. EMBO J. 32(19):2589-602.
Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N et al..  2013.  Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.. Nature. 496(7443):101-5.
Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K, Cantley LC, Heiden MGVander, Vitkup D.  2013.  Heterogeneity of tumor-induced gene expression changes in the human metabolic network.. Nat Biotechnol. 31(6):522-9.
Davis MI, Sasaki AT, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K et al..  2013.  A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.. PLoS One. 8(1):e54127.
Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V et al..  2013.  Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients.. Proc Natl Acad Sci U S A. 110(9):3483-8.
Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RYi, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H et al..  2013.  Influence of threonine metabolism on S-adenosylmethionine and histone methylation.. Science. 339(6116):222-6.
Shyh-Chang N, Zhu H, T de Soysa Y, Shinoda G, Seligson MT, Tsanov KM, Nguyen L, Asara JM, Cantley LC, Daley GQ.  2013.  Lin28 enhances tissue repair by reprogramming cellular metabolism.. Cell. 155(4):778-92.
Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJF, Xu C, Cohoon TJ, Gao P, Zhang Y et al..  2013.  Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer.. Cancer Discov. 3(8):870-9.
Kim SGyun, Hoffman GR, Poulogiannis G, Buel GR, Jang YJin, Lee KWon, Kim B-Y, Erikson RL, Cantley LC, Choo AY et al..  2013.  Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.. Mol Cell. 49(1):172-85.
Lyssiotis CA, Cantley LC.  2013.  Metabolic syndrome: F stands for fructose and fat.. Nature. 502(7470):181-2.
Fendt S-M, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A et al..  2013.  Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.. Cancer Res. 73(14):4429-38.
Song SJung, Poliseno L, Song MSup, Ala U, Webster K, Ng C, Beringer G, Brikbak NJ, Yuan X, Cantley LC et al..  2013.  MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.. Cell. 154(2):311-24.
Csibi A, Fendt S-M, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SMin, Dempsey JM, Parkhitko A, Morrison T et al..  2013.  The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.. Cell. 153(4):840-54.
Lyssiotis CA, Son J, Cantley LC, Kimmelman AC.  2013.  Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance.. Cell Cycle. 12(13):1987-8.