Cantley Lab

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Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You M-H, Yao Y, Kondo A et al..  2015.  Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.. Nat Med. 21(5):457-66.
Douris N, Melman T, Pecherer JM, Pissios P, Flier JS, Cantley LC, Locasale JW, Maratos-Flier E.  2015.  Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.. Biochim Biophys Acta. 1852(10 Pt A):2056-2065.
Denicola GM, Cantley LC.  2015.  Cancer's Fuel Choice: New Flavors for a Picky Eater.. Mol Cell. 60(4):514-23.
Ehrenberger T, Cantley LC, Yaffe MB.  2015.  Computational prediction of protein-protein interactions.. Methods Mol Biol. 1278:57-75.
Sadanandam A, Wullschleger S, Lyssiotis CA, Grotzinger C, Barbi S, Bersani S, Körner J, Wafy I, Mafficini A, Lawlor RT et al..  2015.  A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics.. Cancer Discov.
Begley MJ, Yun C-H, Gewinner CA, Asara JM, Johnson JL, Coyle AJ, Eck MJ, Apostolou I, Cantley LC.  2015.  EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.. Nat Struct Mol Biol.
Denicola GM, Chen P-H, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE et al..  2015.  NRF2 regulates serine biosynthesis in non-small cell lung cancer.. Nat Genet. 47(12):1475-81.
Liu P, Gan W, Y Chin R, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A et al..  2015.  PtdIns(3,4,5)P3-dependent Activation of the mTORC2 Kinase Complex.. Cancer Discov.
Westin SN, Ju Z, Broaddus RR, Krakstad C, Li J, Pal N, Lu KH, Coleman RL, Hennessy BT, Klempner SJ et al..  2015.  PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients.. Mol Oncol.
Dibble CC, Cantley LC.  2015.  Regulation of mTORC1 by PI3K signaling.. Trends Cell Biol.
Kim J-A, Im S, Cantley LC, Kim D-W.  2015.  Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.. Cell Signal. 27(12):2389-2400.
Chakrabarti G, Moore ZR, Luo X, Ilcheva M, Ali A, Padanad M, Zhou Y, Xie Y, Burma S, Scaglioni PP et al..  2015.  Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone.. Cancer Metab. 3:12.
Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio IIn Christi, Giannopoulou EG, Rago C et al..  2015.  Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.. Science.
Lyssiotis CA, Cantley LC.  2014.  Acetate fuels the cancer engine.. Cell. 159(7):1492-4.
Chiu Y-H, Lee JY, Cantley LC.  2014.  BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity.. Mol Cell. 54(1):193-202.
Park SWon, Herrema H, Salazar M, Cakir I, Cabi S, Sahin FBasibuyuk, Chiu Y-H, Cantley LC, Ozcan U.  2014.  BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K.. Cell Metab. 20(1):73-84.
Cantley LC.  2014.  Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar.. BMC Biol. 12:8.
Wang Y-H, Israelsen WJ, Lee D, Yu VWC, Jeanson NT, Clish CB, Cantley LC, Heiden MGVander, Scadden DT.  2014.  Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.. Cell. 158(6):1309-23.
Dasgupta T, Croll DH, Owen JA, Heiden MGVander, Locasale JW, Alon U, Cantley LC, Gunawardena J.  2014.  A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis.. J Biol Chem. 289(19):13010-25.
Chen J, Lee H-J, Wu X, Huo L, Kim S-J, Xu L, Wang Y, He J, Bollu LR, Gao G et al..  2014.  Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain.. Cancer Res.
Cheng H, Liu P, Zhang F, Xu E, Symonds L, Ohlson CE, Bronson RT, Maira S-M, Di Tomaso E, Li J et al..  2014.  A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.. Cancer Res. 74(1):15-23.
Fruman DA, Cantley LC.  2014.  Idelalisib--a PI3Kδ inhibitor for B-cell cancers.. N Engl J Med. 370(11):1061-2.
Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V et al..  2014.  Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.. Nature. 514(7524):628-32.
Thorner J, Hunter T, Cantley LC, Sever R.  2014.  Signal transduction: From the atomic age to the post-genomic era.. Cold Spring Harb Perspect Biol. 6(12):a022913.