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A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.

Date Posted: February 8, 2017

TitleA novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.
Publication TypeJournal Article
Year of Publication2016
AuthorsMullarky E, Lairson LL, Cantley LC, Lyssiotis CA
JournalMol Cell Oncol
Volume3
Issue4
Paginatione1164280
Date Published2016 Jul
Abstract

Serine metabolism is likely to play a critical role in cancer cell growth. A recent study reports the identification of a novel small-molecule inhibitor of serine synthesis that targets 3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the serine synthesis pathway, and selectively abrogates the proliferation of PHGDH overexpressing breast cancer cells.

DOI10.1080/23723556.2016.1164280
Alternate JournalMol Cell Oncol
PubMed ID27652319
PubMed Central IDPMC4972100
Grant ListP01 CA117969 / CA / NCI NIH HHS / United States
P01 CA120964 / CA / NCI NIH HHS / United States
P30 CA046592 / CA / NCI NIH HHS / United States